Psychedelic nasal spray treats depression with toad-inspired goo

A powerful psychedelic compound best associated with the Sonoran desert toad (Incilius alvarius) has been recreated in a lab and transformed into a fast-acting nasal spray. A recent clinical trial outlined this week in the Journal of the American Medical Association (JAMA) suggests this spray could help people with treatment resistant depression, without the often less pleasant element of psychedelics. In the study, a single squeeze of the spray eased patients’ depressive symptoms with benefit