E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding | Science Signaling

13-05-2025 15:01 via science.org

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding | Science Signaling

Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.

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Adherens junctions co-opt EGFR-ERK signaling for epithelial mechanotransduction | Science Signaling

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